以脾指数、病毒抗原阳性细胞、血清ＩｇＧ和脾细胞对刀豆蛋白Ａ的刺激应答为指标，用ＬＰＢＭ５Ｃ５７ＢＬ／６鼠艾滋病模型评价了虎杖水提液的抗病毒作用。结果显示：虎杖水提液可以部分地抑制ＬＰＢＭ５病毒导致的Ｃ５７ＢＬ／６鼠的脾肿大，免疫抑制和病毒血症；病毒接种前和接种同时给药效果较好，接种一星期以后开始的治疗对感染鼠的各项异常指标没有明显的改善作用，提示早期用药效果较好；持续给药可以部分地控制感染鼠脾肿大和脾细胞对刀豆蛋白Ａ的刺激应答降低，但对高球蛋白血症的改善作用是非持续性的。

The effect of Polygonum cuspidatum water extract (PCWE) on C57BL/6 mice infected with LP BM5 murine leukemia virus (MuLV) was investigated taking spleen index, viral antigen positive cell, serum IgG level and ConA response as parameters. It is demonstrated that PCWE can partly inhibit LP BM5 MuLV induecd splenomegaly, immunodeficiency and viremia of C57BL/6 mice.Antiviral effect of PCWE is more effective before or at the same time of virus inoculation than after virus inoculation. It indicates that the earlier treatment, the better. Continual treatment can partly improve splenomegaly and ConA response of infected mice, but the inhibition of PCWE on hypergrmmaglobulinemia of infected mice is non persistent.