Sequencing of the W hole Gene of Hepatitis B Virus

GUO E-Bing; HOU Jin-Lin; DAI Wei; JIA Gang-Xian; P.Karayiannis

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June 1999

GUO E-Bing, HOU Jin-Lin, DAI Wei, JIA Gang-Xian and P.Karayiannis. Sequencing of the W hole Gene of Hepatitis B Virus[J]. Virologica Sinica, 1999, 14(3): 205-209.

Citation: GUO E-Bing, HOU Jin-Lin, DAI Wei, JIA Gang-Xian, P.Karayiannis. Sequencing of the W hole Gene of Hepatitis B Virus .VIROLOGICA SINICA, 1999, 14(3) : 205-209.

乙型肝炎病毒全基因序列的测定

1.
南方医院传染病辩，广州510515
2.
深圳东湖医院，广东深圳
3.
英国伦敦st Mary．s医学院肝病实验室，英国伦敦

摘要

测定7例慢性HBV携带者HBV基因组全序列，经同源性比鞍．确定基因型。2例基因型为B型，余均为C型：血清型adr 4例．adw 3例备序列问X基因差异蛀大未见A 撕、TⅢ2AI 64等重要位点的变异。结合已有的2株HBV中国流行株全基因序列，初步建立以中国流行株序列为基础的HBV标准序列，该标准序列与国外标准序列仅商22个位点的差异。
- 乙型肝炎病毒
- , 基因
- , 序列

Sequencing of the W hole Gene of Hepatitis B Virus

1.
Department of Inf~ctlous Disease,Nanfang Hospital，Guangzhou 510515

Abstract

Seven cases of chronic hepatitis B virus carriers were included for sequencing of whole gene sequences of hepatitis B virus(HBV)．The serotype of 4 strains of HBV weYe adr，and 3 strains were adw．Two strains were dassifled to genotype B．an d the other 5 strains to genotype C．No significant mutations．such as A 。T1762 A1 were present．With other r~oned 2 corn． plete Sequences of HBV strains prevailing in mainlan d China，7 strains of HBV whole sequences of genotype C from mainland Chins were an alyzed to produce the consens us sequence of FIBV of Chlna．Comparing of the consensus sequence with that from Genbanl~．there were only 22 sites with different nucleotides．
- Hepa titis B virus
- , Gene
- , Sequence

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通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Sequencing of the W hole Gene of Hepatitis B Virus

1. Department of Inf~ctlous Disease,Nanfang Hospital，Guangzhou 510515

Abstract: Seven cases of chronic hepatitis B virus carriers were included for sequencing of whole gene sequences of hepatitis B virus(HBV)．The serotype of 4 strains of HBV weYe adr，and 3 strains were adw．Two strains were dassifled to genotype B．an d the other 5 strains to genotype C．No significant mutations．such as A 。T1762 A1 were present．With other r~oned 2 corn． plete Sequences of HBV strains prevailing in mainlan d China，7 strains of HBV whole sequences of genotype C from mainland Chins were an alyzed to produce the consens us sequence of FIBV of Chlna．Comparing of the consensus sequence with that from Genbanl~．there were only 22 sites with different nucleotides．