HCV 6a was expanding and became the predominant subtype among blood donors between 2004 and 2019 in Guangdong, China

Rongsong Du; Ru Xu; Jieting Huang; Hao Wang; Min Wang; Qiao Liao; Zhengang Shan; Huishan Zhong; Yourong Zheng; Xia Rong; Yongshui Fu

doi:10.1016/j.virs.2022.07.005

October 2022

. doi: 10.1016/j.virs.2022.07.005

Citation: Rongsong Du, Ru Xu, Jieting Huang, Hao Wang, Min Wang, Qiao Liao, Zhengang Shan, Huishan Zhong, Yourong Zheng, Xia Rong, Yongshui Fu. HCV 6a was expanding and became the predominant subtype among blood donors between 2004 and 2019 in Guangdong, China .VIROLOGICA SINICA, 2022, 37(5) : 765-768. http://dx.doi.org/10.1016/j.virs.2022.07.005

2004年至2019年间，HCV 6a在中国广东省献血人群中持续扩张并成为最主要的基因亚型

杜荣松 ^a,b ,
许茹 ^a,b ,
黄杰庭 ^a,b ,
王淏 ^a,b ,
王敏 ^a,b ,
廖峭 ^a,b ,
单正刚 ^a,b ,
钟惠珊 ^a,b ,
郑优荣 ^a,b ,
戎霞 ^a,b,, ,
付涌水 ^a,b,c,,

a. 广州血液中心(中国广州 510095);
b. 广州市医学重点实验室(中国广州 510095);
c. 南方医科大学检验与生物技术学院(中国广州 510515)

通讯作者： 戎霞, joyjoy@126.com; 付涌水, fuyongshui@gzbc.org
收稿日期： 2021-10-07
录用日期： 2022-06-15

摘要

慢性丙型肝炎病毒（HCV）感染对中国造成严重的健康负担。然而，中国献血者中HCV基因型的人群分布和时间趋势尚不清楚。基于HCV E1和NS5B基因片段，本研究对2012-2019年间来源于广州血液中心的769名HCV阳性献血者进行了HCV基因亚型鉴定。在这些HCV阳性献血者中，HCV 6a是最主要的亚型，所占比例为41.35%，HCV 1b亚型次之，所占比例为39.92%，其他亚型还包括：3a、3b、2a、1a和4a，所占比例在7.15%到0.13%之间。HCV亚型与人口学特征之间的关联分析显示，男性、年龄较大（≥40岁）和广东省籍献血者中HCV 6a的比例较高，比例分别为43.25%、51.63%和46.75%。而1b则在女性、较年轻者（<40岁）和非广东省籍献血者中相对较多，占比分别为58.12%、45.14%和40.46% 5。纳入2004-2011年数据进行时间趋势分析显示，HCV 6a从34.75%显著增长至44.60%（P<0.05）。值得注意是，HCV 6a在广东省籍献血者中保持高度流行（P>0.05），无明显上升或下降趋势，而在非广东省籍献血者中迅速增加（P<0.05），提示HCV 6a正从广东地区向其它地区扩张。我们的结果提示了持续监测HCV亚型分布的重要性以及实施针对HCV 6a的预防和治疗策略的必要性。
- 丙型肝炎病毒
- , 基因亚型
- , 献血者

HCV 6a was expanding and became the predominant subtype among blood donors between 2004 and 2019 in Guangdong, China

Rongsong Du ^a,b ,
Ru Xu ^a,b ,
Jieting Huang ^a,b ,
Hao Wang ^a,b ,
Min Wang ^a,b ,
Qiao Liao ^a,b ,
Zhengang Shan ^a,b ,
Huishan Zhong ^a,b ,
Yourong Zheng ^a,b ,
Xia Rong ^a,b,, ,
Yongshui Fu ^a,b,c,,

a Guangzhou Blood Center, Guangzhou, 510095, China;
b The Key Medical Laboratory of Guangzhou, Guangzhou, 510095, China (2021–2023);
c Department of Transfusion Medicine, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, 510515, China

Corresponding author: Xia Rong, joyjoy@126.com Yongshui Fu, fuyongshui@gzbc.org
Received Date: 07 October 2021
Accepted Date: 15 June 2022

Abstract

Highlights
1. Currently, HCV 6a has replaced 1b as the most prevalent subtype in blood donors in Guangdong.
2. HCV 6a was the predominant subtype in males and older donors, while 1b predominated in females and younger donors.
3. HCV 6a may expand from Guangdong to other districts of China, and is worthy of attention

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Electronic Supplementary Material

10.1016j.virs.2022.07.005-ESM.docx