
2022年37卷5期
Rotavirus is the leading pathogen that causes severe gastroenteritis in children and infects virtually all children under five years old. Currently only two rotavirus vaccines are licensed in the Chinese market, but the predominant serotypes of epidemic rotavirus are constantly changing. Based on the bovine rotavirus UK Compton strain, a human-bovine reassortant hexavalent rotavirus vaccine (HRV) containing epidemic serotypes G1, G2, G3, G4, G8 and G9 was developed. And phase I and phase II clinical trials showed that this oral hexavalent rotavirus vaccine was well-tolerated and highly immunogenic in infants. In this issue, the subsequent randomized, double-blind, placebo-controlled multicenter phase III trial is reported. Results show that the HRV provides high efficacy against severe rotavirus gastroenteritis (RVGE) and RVGE hospitalization regardless of serotype, without adverse events compared to the placebo group. The cover image shows a shield formed by the hexavalent rotavirus vaccine protecting the infant against the rotavirus infection. See page 724–730 for details.
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中国大陆地区传染性单核细胞增多症住院患儿的流行病学特征和疾病负担:一项全国性回顾性研究
2022, 37(5): 637 doi: 10.1016/j.virs.2022.07.007

2017-2021中国猪流行性腹泻主要流行毒株——NH-TA2020株的分离及口服免疫原性评估
2022, 37(5): 646 doi: 10.1016/j.virs.2022.08.002

柯萨奇B型病毒非结构蛋白2C的解旋酶与RNA分子伴侣活性研究
2022, 37(5): 656 doi: 10.1016/j.virs.2022.05.004

IFITM3的跨膜区结构域负责与流感病毒HA2亚基的相互作用
2022, 37(5): 664 doi: 10.1016/j.virs.2022.07.002

IFN-β1b通过IFN-β1b/JAK/STAT1通路诱导OAS3抑制肠道病毒EV71的复制
2022, 37(5): 676 doi: 10.1016/j.virs.2022.07.013

楸毒素在寨卡病毒感染的早期和晚期发挥抗病毒作用
2022, 37(5): 685 doi: 10.1016/j.virs.2022.07.012

通过使用能模拟病毒粒子组装和释放过程的复制子来比较新冠病毒不同变异株的复制效率以及药物反应
2022, 37(5): 695 doi: 10.1016/j.virs.2022.06.008

中国310例omicron变异株患者的临床特征及与Delta、Beta变异株患者的比较
2022, 37(5): 704 doi: 10.1016/j.virs.2022.07.014
本研究收集并分析了天津市海河医院收治的310例Omicron变异株患者的人口统计学、临床特征和实验室数据。研究将这些患者的数据与在哈尔滨2019年新型冠状病毒病爆发期间的96名Delta变异株患者和326名Beta变异株患者分别进行了比较。
在感染Omicron变体的310名患者中,中位年龄为35岁。大多数患者临床分类为轻型(57.74%),最常见的症状为咳嗽(48.71%)、发热(39.35%)和咽痛(38.26%)。Omicron组不同疫苗接种组的结果显示,接种2剂或3剂后“SARS-CoV-2特异性IgG”的中位数高于未接种组(P<0.05)。根据临床分类,年龄较大的中度病例比例较高,无症状和轻型病例的比例较低。与Delta和Beta组相比,Omicron组的中位年龄更年轻;Omicron病毒组的无症状患者和轻型患者总数高于Delta和Beta组(60.97% vs.54.17% vs.47.55%)。
本研究展示了中国天津市第一组感染Omicron变异体患者的临床特征,并将其临床特征与感染Delta和Beta变异株的患者进行了比较,这将增加我们对奥密克戎变异株的认识。

中国广东和山东省人群中26型和35型腺病毒中和抗体调研
2022, 37(5): 716 doi: 10.1016/j.virs.2022.06.006

口服六价重配轮状病毒活疫苗(Vero细胞)对中国婴儿的有效性、安全性和免疫原性研究
2022, 37(5): 724 doi: 10.1016/j.virs.2022.07.011
结果:口服六价重配轮状病毒活疫苗(Vero细胞)对疫苗所含血清型的轮状病毒所致胃肠炎、严重胃肠炎、因胃肠炎而住院的保护率分别为69.21%、91.36%、89.21%;该疫苗对自然感染的任何血清型轮状病毒所致胃肠炎、严重胃肠炎、因胃肠炎而住院的保护率分别为62.88%、85.51%、83.68%;疫苗组与安慰剂组婴儿接种后30天的不良事件发生率相当,研究期间疫苗组与安慰剂组婴儿严重不良事件发生率没有显著性差异。
结论:口服六价重配轮状病毒活疫苗(Vero细胞)对中国婴儿具有良好的保护效果,且耐受性和安全性良好。

LNP-CpG ODN佐剂的水痘-带状疱疹病毒糖蛋白E在VZV初免的小鼠中诱导与ShingrixTM相当的免疫水平
2022, 37(5): 731 doi: 10.1016/j.virs.2022.06.002

甲型肝炎病毒减毒活疫苗H2株对I型干扰素受体缺陷小鼠的传染性和致病性
2022, 37(5): 740 doi: 10.1016/j.virs.2022.07.009

多靶标mRNA-LNP疫苗诱导小鼠对多血清型DENV的保护性免疫力
2022, 37(5): 746 doi: 10.1016/j.virs.2022.07.003

基于PhIP-Seq技术新筛选出SARS-CoV-2 spike蛋白S2亚基的高亲和力结合短肽
2022, 37(5): 758 doi: 10.1016/j.virs.2022.07.001

新冠德尔塔与奥密克戎患者呼出病毒气溶胶载量与上呼吸道病毒载量均相近
2022, 37(5): 762 doi: 10.1016/j.virs.2022.07.010

2004年至2019年间,HCV 6a在中国广东省献血人群中持续扩张并成为最主要的基因亚型
2022, 37(5): 765 doi: 10.1016/j.virs.2022.07.005

Development of stable, cold-adapted, temperature-sensitive/conditional lethal chimeric enterovirus A71 and coxsackievirus A16
2022, 37(5): 769 doi: 10.1016/j.virs.2022.08.001
1 A stable EV-A71 virus vector was created to generate chimeric enterovirus strains expressing capsid protein genes of EV-A71 subgenogroup C5 and CA16.
2 Phenotypic and genetic stability of the generated chimeric EV-A71 and CA16 were analyzed.
3 The amino acids at the cleavage site between VP1 and 2A is crucial for stability.

Screening for arboviruses in healthy blood donors: Experience from Karachi, Pakistan
2022, 37(5): 774 doi: 10.1016/j.virs.2022.07.008
1 Potential transfusion-related transmission of DENV, WNV and JEV was investigated in healthy blood donors from the blood bank of Aga Khan University during July to December 2018.
2 ELISA for DENV, WNV and JEV IgM antibodies and RT-PCR for viral RNA detection were performed.
3 Of the 360 blood donors screened, IgM antibodies for DENV and WNV were positive in 3.9% and JEV in 0.28% respectively while none of the blood donors tested positive for RT-PCR.
4 Majority of the seropositive donors were between 19 to 30 years of age and residents of urban areas, mainly from Karachi City.
5 DENV and WNV seropositivity were significantly associated with residence in Malir District of Karachi.

不明原因儿童急性严重肝炎:病因分析及下一步的行动
2022, 37(5): 778 doi: 10.1016/j.virs.2022.07.004
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