Severe acute hepatitis in children with unknown aetiology, etiology analysis and the next action

Yuan Gao; Leijie Wang; Lin Wang; Fengmin Lu

doi:10.1016/j.virs.2022.07.004

October 2022

. doi: 10.1016/j.virs.2022.07.004

Citation: Yuan Gao, Leijie Wang, Lin Wang, Fengmin Lu. Severe acute hepatitis in children with unknown aetiology, etiology analysis and the next action .VIROLOGICA SINICA, 2022, 37(5) : 778-782. http://dx.doi.org/10.1016/j.virs.2022.07.004

不明原因儿童急性严重肝炎：病因分析及下一步的行动

高原 ^a ,
王雷婕 ^b ,
王麟 ^b ,
鲁凤民 ^b,c,,

a 首都医科大学北京佑安医院肝四科, 北京 100069;
b 北京大学医学部基础医学院微生物与传染病中心, 北京 100191;
c 北京大学人民医院肝病研究所, 丙型肝炎与肝病免疫治疗北京市重点实验室, 北京 100044

通讯作者： 鲁凤民, lu.fengmin@hsc.pku.edu.cn,lu.fengmin@bjmu.edu.cn
收稿日期： 2022-05-27
录用日期： 2022-07-04

摘要

尽管距离首次报告10例不明原因严重急性肝炎儿童病例已过去近两个月，但将这些既往健康的儿童因严重肝炎送往医院的确切原因仍是个谜。尽管缺乏足够的证据，目前最有吸引力的假设，将不明原因严重急性儿童肝炎的出现和腺病毒感染，这种在患者中检测到比例最高的病原体，和今年年初的omicron感染爆发联系了起来。该假设认为，继发于SARS-CoV-2的腺病毒感染会引发异常的免疫反应和可能的肝损伤。根据该假设，我们认为COVID-19疫苗是否可以预防儿童患上病因不明的严重急性肝炎是一个值得思考的问题，需要进行进一步的探索。
- 重症急性肝炎
- , SARS-CoV-2
- , 疫苗
- , 腺病毒

Severe acute hepatitis in children with unknown aetiology, etiology analysis and the next action

Yuan Gao ^a ,
Leijie Wang ^b ,
Lin Wang ^b ,
Fengmin Lu ^b,c,,

a The Fourth Department of Hepatology, Beijing Youan Hospital, Capital Medical University, Beijing, 100069, China;
b Department of Microbiology & Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, 100191, China;
c Hepatology Institute, Beijing Key Laboratory of Hepatitis C and Immunotherapy for Liver Disease, Peking University People's Hospital, Beijing, 100044, China

Corresponding author: Fengmin Lu, lu.fengmin@hsc.pku.edu.cn,lu.fengmin@bjmu.edu.cn
Received Date: 27 May 2022
Accepted Date: 04 July 2022

Abstract

Highlights
1. MIS-C and severe acute hepatitis might share the common pathogenic mechanism;
2. SARS-CoV-2 persistence throughout multiorgan and tissues;
3. Relationship between COVID-19 vaccines and severe acute hepatitis worth investigating.

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Electronic Supplementary Material

10.1016j.virs.2022.07.004-ESM.docx