Epidemiological characteristics and disease burden of infectious mononucleosis in hospitalized children in China: A nationwide retrospective study

Mengjia Liu; Xinyu Wang; Linlin Zhang; Guoshuang Feng; Yueping Zeng; Ran Wang; Zhengde Xie

doi:10.1016/j.virs.2022.07.007

October 2022

. doi: 10.1016/j.virs.2022.07.007

Citation: Mengjia Liu, Xinyu Wang, Linlin Zhang, Guoshuang Feng, Yueping Zeng, Ran Wang, Zhengde Xie. Epidemiological characteristics and disease burden of infectious mononucleosis in hospitalized children in China: A nationwide retrospective study .VIROLOGICA SINICA, 2022, 37(5) : 637-645. http://dx.doi.org/10.1016/j.virs.2022.07.007

中国大陆地区传染性单核细胞增多症住院患儿的流行病学特征和疾病负担：一项全国性回顾性研究

刘梦佳 ^a,b ,
王心雨 ^c ,
张林琳 ^a,b ,
冯国双 ^c ,
曾跃萍 ^d ,
王然 ^a,b,, ,
谢正德 ^a,b,,

1. 国家儿童医学中心, 首都医科大学附属北京儿童医院, 北京市儿科研究所感染与病毒研究室, 中国医学科学院儿童危重感染诊治创新单元, 国家呼吸系统疾病临床医学研究中心, 教育部儿科重大疾病研究重点实验室, 儿童呼吸道感染性疾病研究北京市重点实验室, 北京 10045;
2. 国家儿童医学中心, 首都医科大学附属北京儿童医院, 大数据中心, 北京 10045;
3. 国家儿童医学中心, 首都医科大学附属北京儿童医院, 病案管理科, 北京 10045

通讯作者： 王然, randall@mail.ccmu.edu.cn; 谢正德, xiezhengde@bch.com.cn
收稿日期： 2022-02-15
录用日期： 2022-07-07

摘要

爱泼斯坦-巴尔病毒（EBV）是一种具有重要临床意义的疱疹病毒，90%以上的成人血清EBV抗体呈阳性。传染性单核细胞增多症（IM）是原发性EBV感染所致的一种主要的临床综合征。IM是一种临床自限性疾病，多数预后良好，但也可发生上气道梗阻、脑炎和噬血细胞综合征等并发症，严重的患儿需要住院治疗。我国关于IM住院患儿疾病负担的研究尚较缺乏。本研究中，我们收集了自2016年1月至2020年12月于福棠儿童医学发展研究中心内的27家三级及以上儿童医院中因IM住院的患儿病案首页信息，对人口信息学资料以及入院时间和住院时长和住院费用等数据进行统计分析。经统计，该五年内共有24120例患儿系因IM住院，占同期全部住院病例的0.42%（24120/5，693262）。IM住院患儿的男女比例为1.48：1，4~6岁年龄组的IM住院率最高。2016~2020年之间，IM住院患儿人数逐年增加，每年7~9月的住院人数及住院率最高，随后逐月下降，1~3月的住院人数及住院率最低。大部分IM住院患儿并无明显并发症，其次支气管炎/肺炎和肝功能损害为两种常见的并发症。IM患儿的住院时长中位数为8天，住院费用支出中位数为970.59美元。本研究将有助于了解我国IM住院患儿的流行病学特征和疾病负担状况，为相关疾病的诊疗和医疗资源配置的优化提供重要数据。
- 爱泼斯坦-巴尔病毒(EBV)
- , 传染性单核细胞增多症(IM)
- , 儿童
- , 流行病学特征
- , 疾病负担

Epidemiological characteristics and disease burden of infectious mononucleosis in hospitalized children in China: A nationwide retrospective study

Mengjia Liu ^a,b ,
Xinyu Wang ^c ,
Linlin Zhang ^a,b ,
Guoshuang Feng ^c ,
Yueping Zeng ^d ,
Ran Wang ^a,b,, ,
Zhengde Xie ^a,b,,

a Beijing Key Laboratory of Pediatric Respiratory Infectious Diseases, Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, Laboratory of Infection and Virology, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China;
b Research Unit of Critical Infection in Children, 2019RU016, Chinese Academy of Medical Sciences, Beijing, China;
c Big Data Center, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China;

Corresponding author: Ran Wang, randall@mail.ccmu.edu.cn Zhengde Xie, xiezhengde@bch.com.cn
Received Date: 15 February 2022
Accepted Date: 07 July 2022

Abstract

Epstein-Barr virus (EBV) is very common, with the infection rate in adults over 90% worldwide. Infectious mononucleosis (IM) is caused by primary infection with EBV. Most IM patients are generally considered to have a favorable prognosis, but a few patients will also develop complications. Children with severe symptoms will require hospitalization. However, the disease burden of children hospitalized with IM in China has been rarely described. In this study, we included the Face sheets of discharge medical records from 27 member children's hospitals of Futang Research Center of Pediatric Development from Jan 1st, 2016 to Dec 31st, 2020, and medical information such as gender, age, region, time of admission, length of stay and expenditure were extracted. There were 24,120 IM cases, which accounted for 0.42% (24,120/5,693,262) of all hospitalized cases during this period. The ratio of male to female was 1.48:1. Hospitalization for IM in the 4–6 years age group was the highest among inpatients of all age groups. Case numbers increased year by year between 2016 and 2020, and the monthly hospitalization was generally high from Jul to Sep but reduced from Jan to Feb per year. Bronchitis/pneumonia and hepatic dysfunction were two common complications in hospitalized IM patients. The median length of stay was 8 days, and the median cost of hospitalization was 970.59 US dollars. This study will help understand the epidemiological characteristics and disease burden of hospitalized children with IM in China.
- Epstein-Barr virus (EBV)
- , Infectious mononucleosis (IM)
- , Children
- , Epidemiological characteristics
- , Disease burden

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