EFFECT OF RIBAVIRIN ON THE SPCEIFIC HUMOUR AL IMMUNITY RESPONSES OF EHF PATIENTS

XIAO Shu-Yuan; Zhu Bao-Lian; Zheng Zhi-Meng; Xiang Jin-Min; J.Meegan; J.W.Leduc; J.W.Huggins; T.Cosgriff; J.I.Smith

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June 1987

XIAO Shu-Yuan, Zhu Bao-Lian, Zheng Zhi-Meng, Xiang Jin-Min, J.Meegan, J.W.Leduc, J.W.Huggins, T.Cosgriff and J.I.Smith. EFFECT OF RIBAVIRIN ON THE SPCEIFIC HUMOUR AL IMMUNITY RESPONSES OF EHF PATIENTS[J]. Virologica Sinica, 1987, 2(3).

Citation: XIAO Shu-Yuan, Zhu Bao-Lian, Zheng Zhi-Meng, Xiang Jin-Min, J.Meegan, J.W.Leduc, J.W.Huggins, T.Cosgriff, J.I.Smith. EFFECT OF RIBAVIRIN ON THE SPCEIFIC HUMOUR AL IMMUNITY RESPONSES OF EHF PATIENTS .VIROLOGICA SINICA, 1987, 2(3) : 41.

病毒唑对EHF患者特异性体液免疫反应的影响

1.
湖北医学院病毒研究所
2.
美国军事医学科学院传染病研究所
3.
美国军事医学科学院传染病研究所武汉

摘要

本文采用微量酶联免疫吸附技术对病毒唑-安慰剂对照治疗流行性出血热(EHF)双盲法临床试验的EHF患者血清特异性IgG及IgM抗体进行了系统的动态观察并比较了两组患者抗体反应水平的差异,发现病毒唑治疗组两种抗体水平均较安慰剂对照组为低(IgG,P<0.001;IgM,P<0.05),说明患者用药后体内特异性体液免疫反应水平有所下降,从而减少免疫复合物的形成,有利于病情改善。

EFFECT OF RIBAVIRIN ON THE SPCEIFIC HUMOUR AL IMMUNITY RESPONSES OF EHF PATIENTS

1.
Virus Research Institute
2.
Hubei Medical College
3.
WuhanU.S. Army Medical Research Institute of Infectious Diseasec

Abstract

Using a micro-ELISA technique, the serum specific IgG and IgM antibody of the EHF patients were measured sequencially as a part of a doubleblind, placebo-controlled clinical trial of ribavirin therapeutic efficacy in the treatment of EHF. The results showed a significant decrease of antibody levels in the ribavirin-treated group (p<0.001 in IgG, p<0.05 in IgM). It suggests that ribavirin has an inhibition effect on the EHF patients antibody responses. Therefore it may reduce the formation of the circ...

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通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

EFFECT OF RIBAVIRIN ON THE SPCEIFIC HUMOUR AL IMMUNITY RESPONSES OF EHF PATIENTS

1. Virus Research Institute
2. Hubei Medical College
3. WuhanU.S. Army Medical Research Institute of Infectious Diseasec

Abstract: Using a micro-ELISA technique, the serum specific IgG and IgM antibody of the EHF patients were measured sequencially as a part of a doubleblind, placebo-controlled clinical trial of ribavirin therapeutic efficacy in the treatment of EHF. The results showed a significant decrease of antibody levels in the ribavirin-treated group (p<0.001 in IgG, p<0.05 in IgM). It suggests that ribavirin has an inhibition effect on the EHF patients antibody responses. Therefore it may reduce the formation of the circ...