POTENTIATION OF INTERFERON S ANTIVIRAL ACTIVITY BY COMBINED PREPARATIONS OF HUMAN ALPHA AND GAMMA INTERFERONS

WANG Jian-Ling; YAN Yong-Jie

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June 1987

WANG Jian-Ling and YAN Yong-Jie. POTENTIATION OF INTERFERON S ANTIVIRAL ACTIVITY BY COMBINED PREPARATIONS OF HUMAN ALPHA AND GAMMA INTERFERONS[J]. Virologica Sinica, 1987, 2(3).

Citation: WANG Jian-Ling, YAN Yong-Jie. POTENTIATION OF INTERFERON S ANTIVIRAL ACTIVITY BY COMBINED PREPARATIONS OF HUMAN ALPHA AND GAMMA INTERFERONS .VIROLOGICA SINICA, 1987, 2(3) : 50.

人α和γ干扰素联合应用的抗病毒协同作用

王建陵 ,
严泳楷

1.
南京中医学院微生物教研室
2.
中山医科大学南京

摘要

采用病毒产量减少试验,在A_(540)细胞上观察α和γ干扰素联合应用的抗病毒协同作用。结果表明:协同倍数为5-16倍;协同作用由干扰素本身的性质所决定,与其它成分无关;α干扰素不能促使γ干扰素加快透生抗病毒状态的建立;故认为协同作用的产生与两型干扰素的细胞受体不同以及抗病毒的生化途径不同有关。

POTENTIATION OF INTERFERON S ANTIVIRAL ACTIVITY BY COMBINED PREPARATIONS OF HUMAN ALPHA AND GAMMA INTERFERONS

1.
Department of Microbiology
2.
Nanjing College of Chinese Traditional Medicine: NanjingSun Yatsen University of Medical Sciences

Abstract

Potentiation of interferon s antiviral activity was determined by replication inhibition of vesicular stomatitis virus in human lung cancer calls(A549). Combined preparations of human IFN-α and IFN-γ interacted with cells synergistically to cause a much grearer level of protection than that expected on the basis of their additive or multiplicative effect. The potentiation was not the artifact of an accelerated development of IFN-γ-induced antiviral resistance in the presence of IFN-α. The rest components in...

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通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

POTENTIATION OF INTERFERON S ANTIVIRAL ACTIVITY BY COMBINED PREPARATIONS OF HUMAN ALPHA AND GAMMA INTERFERONS

1. Department of Microbiology
2. Nanjing College of Chinese Traditional Medicine: NanjingSun Yatsen University of Medical Sciences

Abstract: Potentiation of interferon s antiviral activity was determined by replication inhibition of vesicular stomatitis virus in human lung cancer calls(A549). Combined preparations of human IFN-α and IFN-γ interacted with cells synergistically to cause a much grearer level of protection than that expected on the basis of their additive or multiplicative effect. The potentiation was not the artifact of an accelerated development of IFN-γ-induced antiviral resistance in the presence of IFN-α. The rest components in...