A serologic investigation of epizootic hemorrhagic disease virus in China between 2014 and 2019

Yingliang Duan; Zhenxing Yang; Pei Zhu; Lei Xiao; Zhanhong Li; Zhuoran Li; Le Li; Jianbo Zhu

doi:10.1016/j.virs.2022.06.005

August 2022

Yingliang Duan, Zhenxing Yang, Pei Zhu, Lei Xiao, Zhanhong Li, Zhuoran Li, Le Li and Jianbo Zhu. A serologic investigation of epizootic hemorrhagic disease virus in China between 2014 and 2019[J]. Virologica Sinica, 2022, 37(4): 513-520. doi: 10.1016/j.virs.2022.06.005

Citation: Yingliang Duan, Zhenxing Yang, Pei Zhu, Lei Xiao, Zhanhong Li, Zhuoran Li, Le Li, Jianbo Zhu. A serologic investigation of epizootic hemorrhagic disease virus in China between 2014 and 2019 .VIROLOGICA SINICA, 2022, 37(4) : 513-520. http://dx.doi.org/10.1016/j.virs.2022.06.005

2014-2019年中国流行性出血热病毒的血清学调查

云南省畜牧兽医科学院, 云南省热带亚热带动物病毒病重点实验室

通讯作者： 朱建波, zhujb70@126.com
收稿日期： 2021-12-10
录用日期： 2022-06-13

摘要

流行性出血热病毒（EHDV）属于呼肠孤病毒科环状病毒属病毒。其最早的报道是1955年在美国引起野生白尾鹿的致死性疫病。目前已经在世界多地的多种野生或家养反刍动物身上检测或分离到EHDV。圈养的牛羊被感染后通常为无症状或亚临床症状，但在鹿或牛间爆发过数起流行性出血热疫病。最近20年，有很多株EHDV被分离到并完成测序，因此在全国范围进行EHDV血清学调查具有一定意义。本研究从15个省市的116个地级市收集到圈养反刍动物（黄牛、奶牛、牦牛、绵羊、山羊、鹿）的18，122份血清。EHDV C-ELISA检测结果用于大数据分析。结果在14个省市检出阳性样品，只有平均海拔高于4000米的西藏没有检出阳性样品。所采集样品的EHDV阳性率随纬度增加而降低。牛血清样品的阳性率在0-100%范围，而羊血清样品的阳性率不超过50%。结果说明，对于EHDV，牛明显比羊易感，因此牛可能是国内EHDV的主要病毒库。EHDV的流行性与该病毒的唯一虫媒—库蠓—的分布相一致。南方省份的EHDV阳性率非常高，因此将来应该把南方作为重点监控区。
- 流行性出血热病毒(EHDV)
- , 流行性
- , 反刍动物
- , 中国

A serologic investigation of epizootic hemorrhagic disease virus in China between 2014 and 2019

Yunnan Tropical and Subtropical Animal Virus Diseases Laboratory, Yunnan Animal Science and Veterinary Institute, Kunming, 650000, China

Corresponding author: Jianbo Zhu, zhujb70@126.com
Received Date: 10 December 2021
Accepted Date: 13 June 2022

Abstract

Epizootic hemorrhagic disease virus (EHDV) is a member of the genus Orbivirus, family Sedoreoviridae. It was firstly recognized in 1955 to cause a highly fatal disease of wild white-tailed deer in America. So far, EHDV was detected and isolated in many wild or domestic ruminants, and widely distributed all over the world. Although the domestic cattle and sheep infected by EHDV were usually asymptomatic or subclinical, several outbreaks of epizootic hemorrhagic disease (EHD) in deer and cattle had been reported. Many EHDV strains were isolated and sequenced in last two decades in China, which promoted a general serologic investigation of EHDV in China. In this study, 18,122 sera were collected from asymptomatic or subclinical domestic ruminants (cattle, cow, yaks, sheep, goats, and deer) in 116 regions belonging to 15 provinces in China. All the sera were tested by EHDV C-ELISA, and the results were obtained by big data analysis. EHDV infections were detected in the 14 of 15 provinces, and only Tibet (average altitude ≥ 4000 m) which was the highest province in China was free of EHDV. The numbers of seropositive collections in both bovine and goat/sheep were in an inverse proportion to the latitude. However, the seropositive rates in bovine were ranged from 0% to 100%, while the seropositive rates in goat/sheep were no more than 50%. The results suggested that bovine was obviously more susceptive for EHDV infection than goat and sheep, therefore might be a major reservoir of EHDV in China. The prevalence of EHDV was consistent with the distribution of Culicoides which were known as the sole insect vectors of EHDV. In particular, the seropositive rates of EHDV were very high in the southern provinces, which required the enhanced surveillance in the future.
- Epizootic hemorrhagic disease virus (EHDV)
- , Prevalence
- , Ruminant
- , China

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