2024年39卷3期

Foot-and-mouth disease (FMD) is a highly contagious disease caused by the FMD virus (FMDV). Although the cell receptor for FMDV has been identified, the specific mechanism of FMDV internalization after infection remains unknown. In this issue, Zhang et al. demonstrate that kinesin family member 5B (KIF5B) plays a crucial role in FMDV internalization. KIF5B directly interacts with VP1 to facilitate FMDV internalization by regulating clathrin uncoating. Further evidence indicates that KIF5B also facilitates the transport of viral particles to early and late endosomes during the early stages of FMDV infection. The cover image depicts FMDV (red) ‘hijacking’ host cell protein KIF5B (yellow) to invade the host cell and is then transported by KIF5B to the endosomes for uncoating, releasing RNA for reproduction. Subsequently, FMDV wrests cell resources (blue) within the host cell to complete its own replication, assembly, and release processes, thus completing its life cycle (Kindly provided by Dr. Wei Zhang and Prof. Haixue Zheng). See page 378-389 for details.